The University of North Carolina Wilmington's strength in the natural sciences, especially biological science, chemistry, and other disciplines that form the core of our internationally respected niche in the marine sciences, is the result of decades of intentional focus and investment. In the area of arts and literature, University of North Carolina Wilmington's highest profile programs are in film studies and creative writing. The Department of Film Studies has evolved from a few film-related courses in various departments to a popular major.  The Master of Fine Arts in creative writing has become one of the most respected programs on the East Coast.

The most recent addition to degree programs in the School of Nursing was designed to specifically meet the workforce needs of the pharmaceutical contract research organizations in the region. The Watson School of Education is working to establish the university's second doctoral degree in response to needs expressed by educators in the region, with whom faculty work closely.

The University of North Carolina Wilmington has taken a leadership role in the long-term economic, environmental, educational, social and cultural health of the region. Through the Professional Development System in the school of education, faculty work closely with nearly 100 area schools and agencies to improve the quality of public schools in the region. The School of Nursing has developed collaborative partnerships with area health care providers to give its students a wide range of clinical practice experiences and assist in improving community health care services. There are many different schools within the University of North Carolina Wilmington that will cater to student interests.